I've had some recent experience with this. I'd been trying to fly the Giles VI(65 in. 695 sq.in. 46 oz.) with an la 40, stock muffler. I ended up with a 10/4 APC and 25% nitro. Any less nitro and the motor would overheat and/or not produce enough power(very weather sensitive). Any larger prop would cause the same problems with trying to figure it out compounded by the weather problems.
Found an LA 46 at the hobby shop and said why the heck not. Bolted it in place, with the stock muffler, and the same prop, 10/11/11 fuel and it ran like a top. 11,200 rpm in a fast 4 cycle with very little effect from the weather. Just tweaked the prop pitch a bit to slow it down to a 5.2 lap(62.5 ft lines). I tried an 11/3 APC to slow it down, but it just overheated while flying the same speed. So, get the right prop the motor will run happily. Overprop and it will tend to overheat and be hard to set, as mentioned above.