I wouldn’t expect much aerodynamic difference between having stuff on one side of the fuselage vs. the other, but the mass distribution may matter.
That is one likely issue here, putting all that weight centered ~1" from the centerline of the airplane may overdo the "save tip weight" effect, and require some added to the inboard wing.
I am not sure I would assume the leadouts are going to fix the thrust offset. I know you are skeptical about my assertions about thrust vectors, but I would kick in, or at least make provision for, a good bit of right thrust. Unfortunately the thrust varies all over the place, so no guarantees that you can completely resolve it with thrust offset.
Same effect makes putting the motor straight ahead likely to make for exciting takeoffs, immediate left turn on launch, like an All-American, just not as bad.
Brett