Guitars with MIDI effects and fancy electronic keyboards are cool. But there is simply no denying that the absolute, end all be all, KING of instruments is......
The Wurlitzer Theatre Pipe Organ!
Designed in the teens and refined in the '20's, the Wurlitzer built Hope-Jones Unit Orchestra was the original synthesizer. It replaced entire 40 piece orchestras for the purpose of accompanying silent films and vaudeville acts.
There are a TON of these, but need I say more?