In the few short years that I have been building and flying (so I am by no means an authority on the subject, nor do I pretend to be) I have found if I build all of my planes with the same adjustable ball link control system, so the sensitivity and throw of the controls is always the same, and I ensure everything is zeroed with incidence meters during construction, I can use the same line spacing and never adjust my handle. I also have a clip bender so line length is adjusted with the clips, and I have a set of lines and clips dedicated to each plane, so once again I don't adjust my handle. Since I am simple minded this method takes one piece out of the equation when I'm at the field. Also, I am not a contender to take on the world's best, so the tiny tweaking that might be done with handle adjustments don't make a difference at my skill level, therefore I use the same handle all the time because I really like it and it minimizes the issues with my tendonitis that flares up periodically.
Don