I have been using the Enya 45 6001 dual BB for a year now and I can share my experience with it.
I use a .295 Venturi and the ST 60 NVA fits perfectly. I use Brunie AirFilter which restrict the airflow and simulates a smaller Venturi. On hot and humid days I remove it. 12x6 TF prop with top thined out, more at the tips. 15% Nitro fuel and launch about 8200rpm. The best muffler I found for it is the old Dubro tongue muffler with the spring inside. It is heavy but I needed extra weight on my model so it was good thing. With this setup it runs very steady like a 4S engine.
I have tried to use the original Enya muffler but it didn't work well at all. Used a new Enya muffler that came in with the SS50 and was even worse. Had a custom tongue muffler made and it run great, but with the Dubro muffler it got even better. I think the trick is to have the inside wall of the muffler to match exactly the engine exhaust.
I can make it to do a 4-2-4 using an APC 11x7 and launch at 7600rpm but it didn't pull my Pathfinder with authority. I never tried an 11x8 perhaps that will work better for a 4-2-4 setup.
From what I know the only difference between the Enya 45 6001 and the ST G21 46 is the combustion chamber on the head. The Enya 45 6002 has a similar head of the ST 46 and it will fit perfectly on the 45 6001. I have a brand new 45 6002 head for sale if you want to try one.
Using the higher compression head the 45 6001 will do a 4-2-4 at a higher rpm and I guess will improve power as well.
I have tried the high compression head but I was still using the original muffler. The engine was not running very steady and it flame out after I went inverted

. And didn't persue flying more with it. Now that I have a better muffler for it I'll try the 45 6002 head again and see how it works.
Enya has a much better metallurgy then ST. So you have a great engine in your hands.
Martin