Paul,
It depends on the type of paint you and the reducer/thinner are using. Generally anything under 70% will be fine with dope, LusterKote and Rustoleum. For some auto paints you could go up to to 75%. For the spray cans check the instructions for the humidity limits.
I usually mix my dope at least 50/50, and final clear at 60/40 thinner to dope. A couple tips that make it a little simpler. Go to Walmart and get a combo temperature - humidity gauge. Timing of when you spray is important, in high humidity areas, I find that if you watch the humidity as the day warms usually around 11 am it drops for a few hours, that's when I spray. Also if you are in a "must paint" situation and can't wait you can add some "retarder" but be sure it is either Sig, Randolph or Brodak retarder and don't use more than 8% or it will never dry solid (it will be rubbery). Good luck.
Best, DennisT