Yea, there is no 'best' if it's a sport job, but here's my thinking:
I'm building a half-A flat-wing plane; something that'll go together quickly, fly nicely, and won't make me cry if the winter winds smite it. I'm primarily interested in a paint job that'll keep the fuel and rain off, but something that looks good would be a very big plus.
Right now I'm looking at doing what I know, which is multiple coats of sanding sealer with lots of sanding in between, or cover the whole thing in tissue as a first step, then sanding sealer, hopefully many fewer coats, for a lighter quicker finish.
I'm not looking for a mirror finish -- I can guarantee you that this plane has lost all possible appearance contests and it isn't even built yet.
Suggestions? What's worked for you?