Is it an aluminum venturi? Someone may have opened up the holes to make it easier to put in. I would expect that an aluminum venturi would be less likely to have its holes spontaneously elongate than any plastic, even Delrin. Some el-cheapo plastic venturi (I make mine from an old cutting board, but haven't challenged them with any lean runs yet) might distort from engine heat.
If you have a nice new O-ring, you need to press hard to get the spray bar hole to line up -- if you've got an old hard one, or if someone left it out entirely, then the venturi could well be loose in the hole. I'd check the fit with a new O-ring first. If it's a stock OS venturi then you would ordinarily use a stock, skinny, metric, o-ring -- someone may have substituted an inch O-ring and elongated the hole to match (I make my venturis to take an inch O-ring from the hardware store; if you tried it with a "correct" metric O-ring it's be loose in the hole).