A good argument can be made for saving weight behind the wing, since that also allows a shorter/lighter nose. However, most don't seem to design around that savings. I know I haven't - yet. In my profile originals, I've missed slightly and had to add the weight back at the aft end to get the c.g. right (Ha!). The big thing for me though is not "holes", but structure to stiffen my profile fuselages. I cut out an appreciable portion of half-inch thick fuselage material between the wing and empennage in order to insert diagonal truss bracing. I then use 1/16" balsa sheeting to close the boxes and meet up diagonally with 1/16" ply doublers on the nose for a smooth fit. A 5/8" (legal) profile fuselage results. The plane is markedly stiffer in torsion. Epoxied fiberglass laminated on the bias adds to that, and the fuselage doesn't twist under aero loads. I've had to add over 1/4 ounce to the tail to get the c.g. right; so my weight savings is not important, but if I'd guessed better on nose length, I could have saved enough weight to be worthwhile. Overall, that particular fuselage and plane ended up over five ounces lighter that the original wrecked model with the same wing, smaller tail, and a solid 1/2" thick fuselage, because I saved weight in the narrower silhouette.
(I've posted pictures of that plane too often)
SK