Very interesting topic!
Excuse me for the question first: what do you mean on 4/2 break timing by the HP-40?
Here are my experiences with:
I used many pieces of HP-40 beginning with 1983, up till the end of 1999. Since it was designed originally to R/C, and best performance at 16-17,000 RPM all my pieces were modified, as follows:
-inlet 190° to 170° (some 1/48" thin aluminum "U" profile glued into the window of crankshaft)
-scavenging approx. 125° to 110° and outlet 155° to 140° by sinking down the liner, by machining 1/26" (!!) off the crankcase top
-compression rate adjusted to 1:9 by combustion chamber mod to "trumpet" shape, and thick gasket addition
-all cooling fins machined off from cylinderhead to avoid over-cooling*
-venturi dia. 5.0 millimeters to 5.4 millimeters (no spraybar, but nozzle!)
The engine loved best the 12x5 or 12x4 Tornado props, or wooden copies of them. (Pretty stronger than ST-46)
Fuel consumption was 130 ccm (4.6 fl.oz)
I loved them, and there is one piece still in use, in a 30 years old plane of me, sometimes I used to lend to friends.
*I observed, when the engine is hot enough, the 4-2-4 change is safe and quick enough, and can freely vary with venturi, silencer, etc.
Otherwise not. By a cast iron piston engine (Fox, Veco, etc.) this is not a question, but aluminum piston engines can be overcooled easily, mostly the Schnuerle systems. When the difference between outlet and scavenging is less than 2x15° or at least 2x13° the engine will be unaffordably weak, this is too high price for warm it up.