I do not consider the line separation at the tip to be an aerodynamic factor - except - they shall not 'hang up on each other'!
In terms of trimming, remember: the midpoint between leadout guides is, basically, where line pull aims to the CG. That midline shifts as force increases on the line that moves a control surface out into the airstream. (...and unless total pull changes, that means the other line 'feels' as much less pull at the same time The "Netzeband Wall" is hit when we can't put enough pull on the necessary line to get the model to 'go there.' The smaller the separation between leadouts the less that gap affects your input, but the more chance of fouling the clips...
A wide separation, as shown on many old, old model plans, can involve pitch input if you move the handle forward or aft of the theoretical direct line from handle to CG. (Many early plans showed the guides at the width of the bellcrank, and the leadouts usually perpendicular to the fuselage axis. Not good...)
For me, a slider with an inch between leadouts has been comfortable and dependable.