(True, it's been many decades since I flew profiles powered by heavy vibrators..) When the nose turns into a 1" blur, those short basswood motor mount beams and 1/2" Lite Ply doublers that barely touch the wing LE could have something to do with it!
Ultimately, all that really counts is what works. If lightening long motor mounts by cross drilling the aft portion works well, by all means it should done. I find 3/8" aircraft birch plywood quite rigid. And I enjoy the accuracy and convenience of alignment of a single piece plywood engine crutch.
Losing "most of a doubler", even on one side, is assumed to greatly compromise stiffness? Maybe I'm fostering a mistake - I was just considering tank cutout holes on both doublers, to gain a bit more lateral tank adjustment. (Again, my doublers are 3/32" aircraft birch plywood.)
Virtually all profiles I have built (since 1987) had longer nose moments, say ~9" from spinner back to wing LE. By contrast my experience with vibrating engines was on stock built Flite Streaks {in high school during the 1960s, I built four}, running my worn Fox .35 and the ubiquitous 10-6 Top Flite nylon prop - smaller, shorter coupled models. Perhaps I accidentally avoided resonances; combined with my silky smooth OS .35/.40 and ST .51 engines, I had luck.
I do know once I started recessing fuel tanks in the fuselage, engine runs improved. That, combined with uniflo venting, proper stunt fuel, etc. has greatly enhanced my experience with profile ships.
L.
"You've no idea of what a poor opinion I have of myself, and how little I deserve it." - W.S. Gilbert