FWIW, I would put the four ESCs in the middle and run motor wires out.
Long ESC to battery leads are generally a bad idea, for the reasons mentioned above. (I do have an EE degree

)
Might be heavier than running the battery wires out to ESCs in the nacelles, but at least you know it won't end up causing the ESCs to fail.
(battery wires would need to be thicker than esc-motor wires, so it might be close)
Example below is a "flying beer cooler" B17. Size is very similar to what is being discussed here.
It uses two batteries, so ESCs are connected to them in pairs. Inner motors on one battery, outers on the other.
3 standard Y-connectors to connect all three ESCs to the receiver, or in a C/L example the timer.
With a bit of soldering you could make up a 4 to 1 connector that would be lighter.
Pat MacKenzie