Holes in most any plastic normally drill undersize, ream undersize, and tap undersize. Plastic gets hot as it's being cut, then shrinks when cooling, resulting in undersized holes and tight threads. Better than the opposite condition.
Rule of thumb is to use low rpm, sharp cutters, and pretty heavy feed while making certain to keep the flutes clear...peck drilling. Also, drill a few sizes smaller, let it cool or cool it with cold water (etc.) and then drill it to desired finished size. When I drill a cross hole for a .156" spraybar, I always use a .160" drill. Otherwise, Delrin is really nice stuff...mucho way nicer than the generic stuff they say is "the same thing", "acetyl-acetate". Not the same at all, IMO.

Steve