What comes to mind first is how to deal with the control horns being on fuselage centerline. For a profile, you'll normally need to offset them to one side of the fuselage. With the Nobler's asymmetry, I'd put the horns on the outboard side, to reduce the offset, rather than inside, which would increase the offset. You'd still need to either rework/replace the elevator horn or run the pushrod/horns inside the fuselage. That's been done before, but not real common.
You'd probably lower the thrustline a little bit...not enough to be concerned about aerodynamically, but make sure the LG will be long enough.
Making the profile fuselage both stiff and light is a major problem, but can be managed. I'd suggest a built-up profile with 1/64" plywood on the outside. Either that, or light 1/16" balsa on the diagonal (opposite on L&R sides) with .5 oz CF mat applied with a good hard curing epoxy. There will be other opinions!

Steve