Dennis,
Which exact Byron fuel was added during the second reformulation cycle? Was it Aero Gen II? If so, what oil content and mix? They make several different mixes.
With what you have given us to work with so far, my first thought is that lubricant system keeps getting altered to lower and lower viscosity. This would be due to the ratio of castor to synthetic going down each time you mix it as I suspect that their synthetic has less viscosity than their castor. Since the jet in your needle valve is the same diameter as it was with real Fox fuel, you have to go in on the needle or too much fuel (the reformulated mix) is being drawn by the venturi. If, by turning the needle in, you got at least one run where the power was the same, then that seems consistent to me. If, however turning the needle in did not improve the power back to the previous level, then the new added Byron fuel may have had something wrong with it. For example, if it had absorbed too much water.
But the fuel would not need to be defective to cause what you are describing. If you had to run more than one tank of the stuff thru a Fox Stunt to try to find your setting again, then you are altering more variables since you are removing the "Fox varnish" from the P/L. (If you've been running a mix with synthetic all along, you probably don't have this issue.) And, you may also be changing the heat balance by fooling around simultaneously with the nitro levels (burn rate), and the oil level and type (heat absorption). And running a different fuel but the same plug means whatever the magic setting that went with that plug (and compression ratio) is now different.
If you change fuel mix you have to expect to change the needle. How much you change the needle is a good indication of how consistent your fuel supplier is from batch to batch of even the same fuel mix.
Of course, we are assuming that the only thing that changed was the fuel. No change to the engine, the prop, the tank, the plug, the density altitude, etc.
Dave