The thing you have to be aware of (and correct for if, like the All American, stock asymmetry is excessive) is the fact that the greater the asymmetry the less tip weight you can carry to adjust for the speed/lift differential. The All American is the historically perfect example. At some degree of asymmetry (the AA Sr had a full three inches on just a ~50" span and is the poster plane for what I'm about to write) the spanwise center of gravity will have to be "inboard" of the fuse because the much more than necessary extra inboard wing will now be producing more lift than the outboard and could...if taken even further require weight to be added to the inboard wing to keep the wings level during maneuvering. That would suck but not as much as building it per the plans but using nor (or even very little) engine offset.
The bigger problem (displayed by every AA Sr. built per the plans) is that the spanwise CG can and most likely will end up "inboard" of the thrust line of an engine mounted with little or no offset. The result of this problem is that, upon release, the thrust--being outboard of the spanwise CG--will do its best to accelerate the nose inward toward the pilot rather than straight ahead as more or less demanded by our Jurassic era control system which doesn't adapt easily to slack lines. This has resulted in many an AA Sr. visiting the airman in the center of the circle despite his/her best efforts to outrun the dang thing.
The solution is to defy Brett Buck and all the other experts (such as myself) who preach minimal aerodynamic offsets on our Hot Shot stunters and mount your Fox .35 in the AA Sr. with decided out thrust (four or five degrees) so that the thrust line will pass inboard of the (necessary) spanwise CG location for performing tricks with level wings. Were it not for those pesky "rules" the better solution would be to move the stock wing about two inches outboard resulting in a more modest one inch of asymmetry. Alas, you're unlikely to slip that big a change past the OTS ED.
Ted
p.s. I no longer have my plans for the AA Sr. and can't recall if Hal DeBolt showed a lot of offset or not. The plans do, as I recall, show the ship as he flew it, clockwise. The torque may have helped a bit to keep the outboard wing lower until the ship accelerated but I doubt very much that it would have allowed the engine to have been mounted with zero offset like we're so prone to do with our hot shot ships.
I did pull out my (later designed) de Bolt Stunt Wagon plans, however, which show the flip side of this discussion. The SW had equal span wings (quite unusual for the times, I believe); employed Zero engine offset and called for four (FOUR) ounces of outboard tip weight. By the way, no less a famous and well qualified expert than Al Rabe utilized nothing other than equal span wings and made it quite clear that significant tip weight was required to adjust the spanwise CG to compensate for the greater lift of the faster outboard wing. As with the Stunt Wagon, no engine offset would have been required to avoid the AA Sr takeoff issues. pps, I believe my comment about Al eschewing asymmetry is accurate. There might have been exceptions that I'm unaware of.
Of the two extremes the equal span wings and extra required tip weight is a no brainer superior approach than excessive wing asymmetry. Some of us hot shots could probably make an argument for the superiority of more modest asymmetry, requiring less tip weight set up being closer to the ideal. Both those approaches have admirable records over the years. The AA Sr. approach, not so much.