(Howard is going to point out that nitrate dope is not fuel proof by any means.. which sorta nulls out the "go electric" argument)
I prefer nitrate for attaching silkspan, and use old-fashioned talc mixed in it to make a filler coat. It's stickier and lighter in weight than butyrate, and you can spray butyrate (or most anything else) over it, but not vice versa. It is less tautening (grammar?) than butyrate I believe. Some people use it only on fillets to get better butyrate adhesion and prevent blisters.
IF you spray a wet enough (or "retarder" laden) coat of butyrate over "dry" nitrate, the thinner can dissolve it and you'll get a chemical fight, staged at the molecular level, between nitrate and butyrate. Many people fear that result and avoid nitrate. Also there is the rumor that the slightest scratch in a butyrate top coat can expose the non-fuel-proof nitrate substrate and fuel mist will then destroy your model.
I acknowledge such things can happen and my best advice is "just don't do that"..
Actually, I'd love to find a nice water based non toxic paint with similar gluey, filling, and lightweight properties to replace nitrate dope for use over silkspan. (edit.. I forgot about corn starch)
L.
"Endurance is patience concentrated." -Thomas Carlyle