Jason,
As I think I have mentioned many times, energy is basically equal to weight. As long as you adjust the kV of the motor to match, you can use any combo of cells and capacity to fly the plane. A 6s requires a low kV motor, a 4s a kV ~6/4 (1.5) of the 6s system.
The 4s will use higher capacity cells than the 6s (6/4 times more, or 150% larger), but the result, in the end the capacity and weight are exactly the same. Even the battery "C" capacity will scale ok.
So the main question is how much capacity will you need. Capacity is basically the # of cells times the mAHr of the cell. If you know the total you need, you can divvy it up any way you want. In this case, it may be determined by the kV of the motor you want to buy.
It is natural that as the motor gets physically larger (diameter or length), it's kV tends to get smaller, so yes, so the higher cell count packs also become a no-brainer choice.
I also think the new ICE ESC's which can handle higher voltage packs with ease, also will drive people to use the 6s and larger packs.
If you want to save weight, you ought to look at the Thunderpower Lites. They certainly cost more than the cheaper packs, but they generally are significantly lighter.
Hmmm, if I had bought the Ice 50 with the heat sink, then I might consider 2 4s 2100's in parallel. AFAIK, the 2100's still represent the lightest weight/mAHr of all the cells. I am not too sure why this is the case.