Frank,
A lot depends on what your source for purchasing fuel is. Try to get fuel that has at least 22% total oil for ABC, AAC, ABN (basically modern OS FP's, LA's etc.). If you are running an iron/steel engine (Fox, old OS Max, McCoy's, K&B green heads etc.) you want to get fuel with at least 25 - 28% total oil with at least a 50/50 castor/syn blend (high castor won't hurt up to 90%). For the iron/steel engines stay away from R/C fuels (Cool Power) as they don't run well in stunt (very low oil). With that said most modern engines run well on 10 -15% nitro depending on where you fly (higher altitude like Tucson, AZ run higher nitro). The iron/steel with be running at lower rpm and 5 - 10% nitro is fine.
Read Randy's Care and Feeding article at the top for more information.
Best, DennisT