Yes there have been 100s of people do this, most use a "soft mount" system, there are even soft mount hardware you can buy.
My VECTRA Dreadnought use a soft mount I designed and ran very smooth, the plane is 24 years old and has no cracks from vibration, the controls are still good also, one reason for this was the soft mount, it also helps the plane to be quieter.
Simple way to do this on a profile is to use a RC type mount with rubber encased threaded mounts or use rubber standoffs
Unfortunately, and will all due respect to their advocates, soft mounts are pretty notorious for causing uneven or inconsistent runs, too. In nearly every case, with a precious few exceptions as far as I have seen. David's PA51 example was typical, soft mount, and a new engine. He and we tried every type of engine adjustment, isolated the tank and the fuel filter, the fuel lines changed the stiffness of the rubber grommets, etc all over the place. All sorts of different engine settings, compression, pipe length, fuel and air filters, etc. Finally, put aluminum spools where the rubber went, and within 1/4 lap of takeoff it was clear that it was solved, and the engine ran perfectly. And this is just an example of something that I have seen repeated many times. And the 51 is not known as a real shaker, certainly not as much as the 61/65/75
If you really know what you are doing, and want to try it, make sure you have isolators of many different stiffnesses from dead soft to aluminum/steel. I would suggest starting with the engine mounted rigidly, and get it working perfectly like that. Then and only then, put in flexible isolators. This permits to reduce any problems you have to only the isolator stiffness, and not an engine setup issue. Beyond that, I have no idea how you evaluate whether they are too stiff, or too soft, or somewhere in between based on how the engine runs.
It definitely does isolate vibration. In fact on David's airplane, it started out with a radial mount of something like 1/16 or .080 aluminum plate (held by the backplate screws), and that was fine as long as the rubber mounts where there. Once it was clear that it worked vastly better with solid mounting, the backplates started cracking. I think it went from .080 6061 to 3/32, then 3/32 steel, and maybe even 1/8 steel now. It still cracked in pretty short order. It has many cutouts for fuel tubing, etc, but still, very thick steel was cracking.
Brett