When you look at the aerodynamics, mainly of the wing, the outboard wing flys faster than the inboard wing. Wild Bill had the formula someplace. It depends solely on the wingspan related to the line length. So on a 48 in. plane with equal panels the aerodynamic center of the wing is about .44 in. to the right of the centerline. On a 60 in. plane it would be about .6 in. This gives you a couple(unbalanced force) between the thrust line and the center of drag, on a full-bodied stunter that is always turning the plane out of the circle. Profile planes lose some of this couple because the width of the fuselage subtracts from the wing aero offset, reducing the force.
On a profile you can get the couple back by aiming the thrustline so it crosses the wing centerline close to the quarter chord of the wing. Then the force layout is almost identical to a full-bodied plane. Adding washers under the front engine bolts works, but is hard on the case and motor mounts. I've had much better success cutting the angle into the motor mounts, usually about 3/32 in. in the about 1.5 in. where the motor bolts up. Make sure to angle the bolt holes to match and the bolts will love you.
You can add to the effect by making the outboard wing a little larger(a few square inches). Some folks do this by enlarging the outboard flap. Then you need to balance that by adding either more tip weight, and/or moving the leadouts back a bit. Other folks eliminate the couple by making the inboard wing a few square inches larger by making it half an inch or so longer. That simplifies some trim problems but introduces a few also.
The bottom line is no matter what you do the plane is assymmetric when it is flying because the outboard wing flies further than the in board wing. All the trimming and design tricks are aimed at minimizing this effect on the plane in maneuvers, but in the end they are only perfect for one speed and one attitude. So just get it close to some happy medium.
One advancement you can't use in PA yet is Spectra lines. They weigh about 1/6 of what stainless steel lines weigh. The low weight almost completely eliminates any effects from the bow in the lines swinging around as the plane maneuvers. The weight of the lines usually shows up in the maneuvers with turns of a tight radius. The plane slows, the backwards bow in the lines kind of rolls down the lines, usually just in time to jerk the plane as the next corner is starting.