Built-up fuselage? Flat sides and formers, with round deck and belly?
Stiff how? Do you mean as an appliance to hold the tail in an exact relationship to the wing, or do you mean as something that'll paint up nice?
I don't think there's any one right answer, or even any one answer.
More formers means fewer "wows" in the fuselage sides -- but you can get the same effect with an all-molded fuselage and fewer formers, because the fuselage skin will serve to stiffen itself.
You'll lose a perfectly flat side and its pretty finish long before you'll lose wing-to-tail rigidity.
You could probably do a super-zoot three-layer epoxy-carbon/foam/epoxy-carbon layup, with no formers at all -- you can probably make that superbly stiff and light, at the cost of a lot of work. (Don't tell Howard that -- we want him to have a plane for Poland).
If you're going to stick with a "box and turtle-deck" fuselage then lots of lightweight formers is probably a good idea. Paul Walker's Impact that he published in 1991 in Flying Models has nine -- count 'em -- former stations along the length of its fuselage. But that plane has tall flat sides -- had he made the sides convex, or had he made them out of thicker material, or had he been willing to put up with more waviness in the finish, he could have used fewer.
It'd be interesting to know how many formers Igor Burger used in his GeeBee, with its all-molded sides.