I really am not that good at estimating model sizes for "big" airplanes. I would look at the most competitive designs in that engine size and add 15% to the area. Since you don't have a big fuselage or horizontal tail, you can put that area back into the wing.
Once that is done, take the ratio off New Aera/Old Area and take the square root of that. This is your linear magnification requirement. When in doubt, go to the next wood size UP! It goes the other way scaling down.
Take a scale up to 600 sq. in. for example. 600/250=2.4, the square root is 1.54 so you have a 54% linear magnification. Anyway, that is the technique.
As far as structure, say you have 1/8" stock in the small model. Tines 1.54, that comes to .19" for the big one, so go to 1/4".